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NSM Biologics Biosynthetic Skin Substitutes

NeoThelium™: Layered for Protection

NeoThelium™ products provide protective coverage from the surrounding environment for acute and chronic wounds. All NeoThelium™ products retain the spongy (intermediate) layer.

NeoThelium™ FT

Q4387

Full-Thickness Amnion/Spongy/Chorion Allograft

NeoThelium™ 4L

Q4388

Full-Thickness  Amnion/Spongy/Chorion/Chorion/Spongy/Amnion Allograft

NeoThelium™ 4L+

Q4389

Full-Thickness  Chorion/Spongy/Amnion/Amnion/Spongy/Chorion  Allograft


Spongy Layer: A Reservoir of Key Growth Factors and Matrix Proteins

The spongy (intermediate) layer is a rich source of bioactive molecules, comprising essential growth factors and matrix proteins such as hyaluronic acid (HA), transforming growth factor beta 1 (TGF-β1), hepatocyte growth factor (HGF), and interleukin-1 receptor antagonist (IL-1Ra). Note: These components are naturally found in the spongy layer; their specific activity in NeoThelium™ products has not been evaluated.


Layered Solutions for Diverse Clinical Needs.

NeoThelium™ FT  

A full-thickness Amnion/Spongy/Chorion allograft designed for single-use as a wound covering. Its two-layer composition offers a straightforward, natural option for a variety of clinical applications. Each layer is preserved to maintain the inherent properties of the tissue, delivering a streamlined solution for coverage needs. 

NeoThelium™ 4L  

A full-thickness Amnion/Spongy/Chorion/Chorion/Spongy/Amnion  configuration, creating a four-layer structure for single-use wound covering applications. The unique layering provides a robust, naturally derived option for clinicians seeking a multi-layer format, while maintaining the characteristics of the source tissue. 

NeoThelium™ 4L+ 

A full-thickness Chorion/Spongy/Amnion/Amnion/Spongy/Chorion allograft designed for single-use as a wound covering. Its distinctive four-layer arrangement offers an alternative structural configuration within the NeoThelium™ portfolio, providing clinicians with another naturally derived option while retaining the integrity of the original tissue composition. 

NeoThelium™ is an amniotic membrane allograft derived from a prescreened mother with a planned delivery. NeoThelium™ is manufactured in compliance with FDA regulations. The membrane is minimally processed to preserve the native structure of the tissue, dehydrated, and terminally sterilized. NeoThelium™ is confirmed by the FDA Tissue Reference Group to meet the criteria for regulation solely under Section 361 of the PHS Act as defined in 21 CFR Part 1271.

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